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I don't see how taking time off would hurt anything. I've had 2 IUI and had to take a month off in between each one cuz of cysts. The RE didn't make a big deal out of it, just have to call at the beginning of the next cycle. And we try on our own anyway during the off months (no meds).
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Me (33) Unexplained Infertility
DH (36) Good, Great
9/06 - surgery, removed Stage 4 endo
6/07 - first try clomid
7/07 - u/s showed cyst
9/07 - surgery, cyst removed
12/07-02/08, clomid & timing
3/20/08 - first IUI 
4/08/08 - u/s showed cyst
5/13/08 - u/s - good to go 
5/29/08 - 2nd IUI
6/12/08 - beta bloodwork
6/12 - CD1
6/16 - u/s, new cyst 
waiting for next cycle - still waiting
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