Hi! My husband does not have Kleinfelter's Syndrome, however, he does have a chromosomal balanced translocation which gives us an extremely high rate of miscarriage(I had one before my daughter and 4 after). We do have one biological child that we are VERY lucky to have (we didn't know about my husband until after my daughter). Anyway, my point is that I can relate because my husband has "good" and "bad" sperm so if we do infertility tratments we have to do ivf with pgd (preimplantation genetic diagnosis) and icsi. My sister in law did the above procedure in Chicago and was lucky as out of 20 eggs she had 2 "good" fertilized ones and after ivf she has a beautiful daughter after her first try.So there is hope. I thought maybe this website might be able to help you out. www.reproductivegenetics.com