My husband was diagnosed with Kleinfelter's Syndrome in Spring 2001, after having 2 semen samples come back with a zero sperm count and then having bloodwork done to check his chromosomes. He is a mosaic Kleinfelter's, some of his cells are normal, but many are not. He presents as "normal" in every way outwardly and physically, so this diagnosis came as a big shock to us.

He was put on a testosterone cream because his hormone levels were out of whack. They are now all in the normal range.

Our endocrinologist says because my husband is a mosaic, he may be able to father a biological child through IVF, ICSI. We decided to put all that on hold and adopted two older children instead. We are now in the process of adding another child to our family as well.

I am interested though, in hearing from anyone else who has experienced Kleinfelter's, and to see if anyone has successfully had a biological child after this diagnosis.

Thanks!

Hi! My husband does not have Kleinfelter's Syndrome, however, he does have a chromosomal balanced translocation which gives us an extremely high rate of miscarriage(I had one before my daughter and 4 after). We do have one biological child that we are VERY lucky to have (we didn't know about my husband until after my daughter). Anyway, my point is that I can relate because my husband has "good" and "bad" sperm so if we do infertility tratments we have to do ivf with pgd (preimplantation genetic diagnosis) and icsi. My sister in law did the above procedure in Chicago and was lucky as out of 20 eggs she had 2 "good" fertilized ones and after ivf she has a beautiful daughter after her first try.So there is hope. I thought maybe this website might be able to help you out. www.reproductivegenetics.com

Hi Holly.
My husband also has Kleinfelter's Syndrome. He has known a long time that he had this. We have adopted a baby boy in October of 2003.

Could you tell me if you know of what percentage of men with 0 sperm count have Kleinfelter's Syndrome? Sorry I didn't have any information to offer you.

[zon]

Holly
I just want to reply to your questions. I know a gril that I've been talking to just got pregnant with the second child thrue TESE/IVF/ISCI and her DH has Klinefelter's syndrome. They don't know if he's mosaic as the doctor they went to did not care about it. He gave them 75% chance of finding sperm and he did. It's vey new and a lot of doctors don't know that is possible to find sperm in men with KS. If I remember correctly he was able to find sperm in 60% of men with KS.
We are in the same situation and we will be going thru TESE/IVF/ISCI in December. My DH also looks "normal" and he had no idea. We also don't know if he's mosaic or not as the doctor dosen't agree with this theory. I'm very nervous but optimistic. I'll let you know in couple of month if we were successful.


Just want you to know that there is a great doctor out ther that helps with KS now.

[anthonysgirl]

Hi Holly,

My younger brother has Klinefelter's Syndrome, not Klinefelter's mosaic, but full-on klinefelter's; there are differences between the 2. He was diagnosed with it when he was 4 y/o. He has been to many, MANY doctors, and they have all said the same thing, that he will never be able to father a child.
Having a family member with the condition, and being a biology major myself, I have done a lot of research on the topic, and all that I have read has said that boys/men with KS, cannot father children naturally. Nothing has ever been mentioned about IVF though.
Stay positive, everything happens for a reason.
Good luck, hun.
Christina

[ExtraChrispy]

I was "fortunate" enough to be diagnosed with Kleinfelter's as a child, although this was at a time when not much was known about the whole "syndrome" (which has since been re-defined).
I am now 41 y.o.a. I have "known" for about the last 30 years of my life that the chances of my "siring" my own children were virtually nil.
I welcome all serious questions, and will answer them to the best of my abilities.
I was involved in, what, at the time, was known as the "Child Development Study", headed by Drs. Theodore Puck & Arthur Robinson, (variously working at or through) The University of Colorado Health Sciences Center (University Hospital) and/or the National Jewish Hospital, Denver.