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07-17-2008, 10:00 AM
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Metformin questions
I have been on metformin for about 2 weeks and just increased to 500mg 2 times a day. I have been noticing that I get really shaky before meals. Could this be because my blood sugar is dropping from the metformin. Is it possible for you blood sugar to drop when you are taking it? I also have been having trouble w/ sleeping. I wake up and I feel like I am not rested and have just been generally fatigued. I have not had any problems w/ diarrhea, but I am getting some occasional nausea, esp in the morning.
Could someone let me know if these are some common side effects? I am afraid to increase the dose
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Me, 33- pcos, only one working fallopian tube DH, 37- ok count, 0% morph, slightly low motility  - yellow lab, GingerHSG- left tube ok, right tube "not found", 2 uterine defect fillings found 2/27-had Lap and Hysteroscopy. 2 polyps removed and some scar tissue. right tube ok, now left tube blocked. 6/17- planning on IVF in September waiting for  to start bcp, maybe wk of 7/217/20--- started on bcp, scheduled for another hysteroscopy on 8/15 Starting Lupron on 8/22, stopping bcp on 8/29 Starting Stims 9/4 ER 9/18-------9 eggs retreived all mature and fetilized!! ET 9/22----Transfered 3 embies 10/2 Beta#1 = 114  10/6 Beta#2 = 488  10/9 Beta#3 = 1600, first us nothing seen yet 10/16 US #2 It's twins!!!  10/24 US#3 NOT TWINS....TRIPLETS!!  
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07-17-2008, 11:14 AM
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I have been taking it for 2 months now,have the same side effects as you.For some ,they go away after a couple of weeks,but i do have them still,i stopped taking them after my IUI,will be back on them,if i get a BFP/BFN this cycle.
There's also Metformin(Extended release),i heard they dont have as many side effects as Metformin(regular),but my RE presribed Metformin(regular),and asked me to take fluids,preferred more water though. Hope this helps.
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ME 28(PCOS) DH 32(Low Mot@Mor) IUI # 1 , Aug 07 , C(100 mg), 1 Follie  IUI # 2 , Sep 07 , C+F(150IU),3 Mature IUI # 3 , Jan 08 , C+G-F(150IU),Mild OHSS,BD'd IUI # 4 ,July 08 , C+Gl-F(75IU), IVF # 1 BCP : Sept 26th -- Oct 16th Oct 1 : RE Apt Oct 8 : Saline Sono, Mock Tansfer Oct 10 : CD(Cervical Dilation) Oct 13 : Depot Lupron (1 Time ) Oct 20 : AF Oct 22 : U/S , B/W Oct 24 : Gonal-F(75iu),Menopur( 1 Vial ) Oct 29 : U/S , B/W ( 15 Follies,all 9-10mm ) Oct 31 : U/S , B/W (15 Follies ,12-15mm) Nov 02 : U/S,B/W (14 Follies, 1@22mm,1@21mm,15-18mm Nov 03 : U/S,B/W (9-10 Mature,3@13mm)(Trigger) Nov 05 : ER ( 11 eggs,10 Fertilized,PIO) Nov 09 : ET ( 4 DT) Nov 12 : P(43.6),E2(1549) Nov 18 : 9DP4DT , 2 +HPT's Nov 19 : + HPT , BETA Nov 20 : BETA result : +ve, 397 Nov 22 : 2nd BETA scheduled 
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07-17-2008, 12:31 PM
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If you're getting shaky, it sounds like your blood sugar is indeed dropping. It's completely possible on the metformin.. it happens to me occassionally. I would definitely talk to your doctor about it.. you might be on too high a dosage if this is happening often. At least that how it seems to me, since metformin helps the insulin your body makes to be more effective in processing your blood sugar. I don't know about the fatigue and nausea.. those were never side effects for me.
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Me (Jenny): 27 - PCOS, hypothyroid DH (James): 29 - Slightly low morphology TTC 3+ years; 1st year and a half wasted with a worthless doctor 2007 2 failed Clomid cycles Ectopic pregnancy  2008 3/5 - new cycle - Clomid and Follistim 3/31 - positive hpt 4/2 - 1st beta - 48.5! Estrogen 324, Progesterone 35.9 4/4 - 2nd beta - 113.8! 4/7 - 3rd beta - 487!! 4/11 - 4th beta - 2987  4/16 - 1st u/s - 1 beautiful healthy peanut in exactly the right place! 4/23 - 2nd u/s - everything still great. Saw and heard the heartbeat! 122bpm! 5/6 - 3rd u/s- Absolutely amazing. Measuring 8w6d, 172bpm; released to OB 6/4 - Everything is still perfect. Measuring right on track, hb 161bpm 6/26 - Couldn't be better; 148bpm 7/21 - Anatomy Scan!! It's a GIRL!   "And when the night is cloudy there is still a light that shines on me. Shine until tomorrow, let it be."
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07-20-2008, 05:09 PM
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I had those same symptoms when I first started the metroformin. I had to work my way up to taking 3 pills a day. The first week I took one pill and then the next 1/2 and so on and so on. I am taking the medicine along with excercise and doing the southbeach diet.
Good luck 
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Me: 34 - PCOS DH: 37 Trying for 4 Years 04/06 - 11/06 - Clomid and Ovidrel - BFN 09/06 - Gonal F with Ovidrel - BFN IVF #1 - with ISCI 2/6 - ER - 13 of 15 Eggs Fertilized 2/11 - ET - 2 Blasts 2/20 - Beta #48 (please rise!)2/22 - Beta #80 (please keep rising!) 2/24 - Beta #172 !!!!! (horray it acutally doubled)  3/1 - Beta #1376!!!!! U/S sak is detected!!!!!! 3/7 - Beta #5,723 - Saw our little bean 3/12 - Beta #13,551 - Saw our little bean again but no heartbeat yet. 3/15 - No Heartbeat - Miscarried D&C done at 7 WeeksFET- 3/28/08 - Transfered 1 Blast 4/6/08 - Beta IVF#2 10/7/08 - Retrieved 14 eggs - 12 Fertilized 10/11/08 - Transfered 2 and Froze 7 10/24/08 - Beta#1 - 172 10/31/08 - Beta#2 - 1,848 11/6/08 - Beta#3 - 8,337 Pogs over 40 1 bean detected on U/S 11/13/08- U/S Heartbeat - 126BMP Beta 32,668 Pog over 4011/20/08- U/S Heartbeat - 146BMP Beta 77,790 pog over 40
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