[wiedensd]

Sorry, I don't know lots of abbv. cuz I'm new to forums, but here is my question/story.

Has anyone with PCOS had a miscarriage & D&C with endometrial tissue biopsy, and what did it/can it reveal?

I wad dxd with insulin-resistant PCOS in 2003 by a Reproductive Endocrinologist, but the OBGYN I seen didn't really believe I had it based on his prelim. testing, but neither did the Endo doc until he did extensive testing.

OBGYN found I wasn't ovulating, but didn't believe it was from PCOS. But strangely, he offered to put me on Metformin or Clomid to see if I would get pregnant. (P.S., I'm 35). I chose Clomid and got pregnant on the first try, but I miscarried somewhere around week 8, but didn't have any symptoms of miscarriage, and still don't, but there was no heartbeat on ultrasound at 12 weeks and the size of embryo was 7.4 weeks. I have a D&C on Wed.

Since learning of miscarriage, I've been reading up on the rate of miscarriage of women with PCOS and how women with insulin-resistant PCOS can have poor egg quality and also possible luteal phase defect. I'm wondering if there are any tests that can be performed duirng the D&C that will tell me if this miscarriage was PCOS/hormone related. . . . Or if it is simply a chromosomal abnormality like the OBGYN seems to think it was.

Thanks.

[slobin]

I'm so sorry about your loss. There is more obscure testing that they won't do automatically but can reveal other problems. You can send tissue from your D & C to a reproductive immunologist who will test for immunological causes of miscarriage such as blood clotting, elevated NK cells etc. If you're interested in that you can go to www.repro-med.net and under "immunological testing" there is a section that explains the method for having the tisse sent to a lab for analysis.

I have had 2 miscarriages after IF and I know the heartbreak! I hope you get some answers.

Slobin